PABPC1, poly(A) binding protein cytoplasmic 1

PABPC1, poly(A) binding protein cytoplasmic 1

• This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

• Gene Synonyms (PAB1, PABP, PABP1, PABPC2, PABPL1, polyadenylate-binding protein 1, poly(A) binding protein, cytoplasmic 2,)
• NCBI Gene ID: 26986
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R9C1
  UNIPROT ID#>>P11940
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(A) binding protein cytoplasmic 1 interacts with:

• agrin
  anaphase promoting complex subunit 5
  argonaute RISC catalytic component 2
  autophagy related 16 like 1
  biogenesis of ribosomes BRX1
  bromodomain containing 7
  CCR4-NOT transcription complex subunit 6
  CCR4-NOT transcription complex subunit 7
  CDK5 regulatory subunit associated protein 2
  coiled-coil domain containing 8
  cullin associated and neddylation dissociated 1
  DDB1 and CUL4 associated factor 4 like 2
  DEAD-box helicase 19A
  defective in cullin neddylation 1 domain containing 1
  expressed sequence AI837181
  HAUS augmin like complex subunit 1
  immunoglobulin superfamily member 8
  integrin alpha FG-GAP repeat containing 1
  itchy E3 ubiquitin protein ligase
  La ribonucleoprotein 7, transcriptional regulator
  LUC7 like 2, pre-mRNA splicing factor
  maelstrom spermatogenic transposon silencer
  methylphosphate capping enzyme
  mex-3 RNA binding family member A
  mex-3 RNA binding family member B
  mex-3 RNA binding family member C
  musashi RNA binding protein 2
  PIH1 domain containing 1
  PIN2 (TERF1) interacting telomerase inhibitor 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein interacting protein 2
  poly(A) binding protein interacting protein 2B
  poly(A) polymerase beta
  poly(A) specific ribonuclease subunit PAN3
  protein arginine methyltransferase 6
  PTEN induced kinase 1
  R3H domain and coiled-coil containing 1 like
  regulatory associated protein of MTOR complex 1
  ring finger protein 31
  RIO kinase 1
  SH3 domain containing kinase binding protein 1
  sirtuin 7
  splicing regulatory glutamic acid and lysine rich protein 1
  synaptonemal complex protein 3
  tet methylcytosine dioxygenase 2
  TNFAIP3 interacting protein 2
  transformer 2 alpha homolog
  trinucleotide repeat containing adaptor 6A
  trinucleotide repeat containing adaptor 6C
  tropomodulin 3
  tudor domain containing 3
  ubiquilin 2
  ubiquitin protein ligase E3 component n-recognin 5
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 10
  zinc finger FYVE-type containing 21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.