CDK5RAP2, CDK5 regulatory subunit associated protein 2

CDK5RAP2, CDK5 regulatory subunit associated protein 2

• This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

• Gene Synonyms (C48, Cep215, MCPH3, CDK5 regulatory subunit-associated protein 2, CDK5 activator-binding protein C48, centrosomal protein 215 kDa, centrosomin,)
• NCBI Gene ID: 55755
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z3M0
  UNIPROT ID#>>B9EG74
  UNIPROT ID#>>B3KVI2
  UNIPROT ID#>>Q96SN8
  UNIPROT ID#>>A0A0A0MRG9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CDK5 regulatory subunit associated protein 2 interacts with:

• AHNAK nucleoprotein
  baculoviral IAP repeat containing 6
  caspase recruitment domain family member 9
  centrosomal protein 43
  charged multivesicular body protein 4B
  chromosome 1 open reading frame 87
  chromosome 6 open reading frame 141
  coronin 1B
  dystrobrevin binding protein 1
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 81 member B
  H2A clustered histone 12
  H2B clustered histone 12
  IKBKB interacting protein
  mitotic spindle organizing protein 2A
  mitotic spindle organizing protein 2B
  MUS81 structure-specific endonuclease subunit
  RNA binding motif protein 48
  StAR related lipid transfer domain containing 9
  SUMO specific peptidase 2
  TNFAIP3 interacting protein 2
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tubulin gamma complex associated protein 5
  tubulin gamma complex associated protein 6
  ubiquitin specific peptidase 43
  USO1 vesicle docking factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.