IGSF8, immunoglobulin superfamily member 8

IGSF8, immunoglobulin superfamily member 8

• This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

• Gene Synonyms (immunoglobulin superfamily member 8, CD81 partner 3, glu-Trp-Ile EWI motif-containing protein 2, keratinocytes-associated transmembrane protein 4, prostaglandin regulatory-like protein, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL,)
• NCBI Gene ID: 93185
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q969P0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

immunoglobulin superfamily member 8 interacts with:

• diacylglycerol lipase beta
  dynein axonemal heavy chain 14
  eukaryotic translation initiation factor 3 subunit C like
  H2B clustered histone 1
  H2B clustered histone 18
  H3 clustered histone 14
  heterogeneous nuclear ribonucleoprotein A3
  keratin associated protein 10-3
  keratin associated protein 10-4
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 2-3
  keratin associated protein 5-7
  metallo-beta-lactamase domain containing 2
  occludin
  transmembrane protein 30B
  tubulin beta class I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.