RPTOR, regulatory associated protein of MTOR complex 1

RPTOR, regulatory associated protein of MTOR complex 1

• This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

• Gene Synonyms (KOG1, Mip1, regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, raptor,)
• NCBI Gene ID: 57521
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N122
  UNIPROT ID#>>Q6DKI0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulatory associated protein of MTOR complex 1 interacts with:

• AKT1 substrate 1
  BRCA1 associated ATM activator 1
  cingulin
  DENN domain containing 1A
  denticleless E3 ubiquitin protein ligase
  DEP domain containing MTOR interacting protein
  egl-9 family hypoxia inducible factor 3
  GRB10 interacting GYF protein 1
  HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
  immunoglobulin lambda like polypeptide 5
  IQ motif containing F1
  leucine rich repeat and fibronectin type III domain containing 1
  lipin 3
  microtubule affinity regulating kinase 4
  MTOR associated protein, LST8 homolog
  mucin 19, oligomeric
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  pleckstrin homology domain containing A4
  Ras related GTP binding C
  Ras related GTP binding D
  regulatory associated protein of MTOR complex 1
  regulatory associated protein of MTOR, complex 1
  RPTOR independent companion of MTOR complex 2
  thioredoxin domain containing 15
  TIR domain containing adaptor protein
  tubulin beta 8 class VIII
  tubulin beta class I
  unk zinc finger
  zinc and ring finger 2
  zinc finger imprinted 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.