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DENND1A, DENN domain containing 1A

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DENND1A, DENN domain containing 1A

  • Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

  • Gene Synonyms (FAM31A, KIAA1608, DENN domain-containing protein 1A, DENN/MADD domain containing 1A, connecdenn 1,)
  • NCBI Gene ID: 57706
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>Q9HCG4
    UNIPROT ID#>>Q8TEH3
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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