YTHDC2, YTH domain containing 2

YTHDC2, YTH domain containing 2

• This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]

• Gene Synonyms (3'-5' RNA helicase YTHDC2, CsA-associated helicase-like protein, probable ATP-dependent RNA helicase YTHDC2, CAHL, hYTHDC2,)
• NCBI Gene ID: 64848
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H6S0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

YTH domain containing 2 interacts with:

• coiled-coil domain containing 8
  cyclic GMP-AMP synthase
  nucleolar protein interacting with the FHA domain of MKI67
  ribosomal protein L35
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  signal recognition particle 72
  ubiquitin specific peptidase 42
  zinc finger and BTB domain containing 38
  zinc finger protein 324B
  zinc finger protein 512
  zinc finger protein 550

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.