RBFOX2, RNA binding fox-1 homolog 2

RBFOX2, RNA binding fox-1 homolog 2

• This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RNA binding protein fox-1 homolog 2, RNA binding protein, fox-1 homolog 2, RNA-binding motif protein 9, fox-1 homolog B, fox-1 homologue, hexaribonucleotide-binding protein 2, repressor of tamoxifen transcriptional activity, FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh,)
• NCBI Gene ID: 23543
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43251
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA binding fox-1 homolog 2 interacts with:

• ankyrin repeat domain 40
  aph-1 homolog A, gamma-secretase subunit
  ataxin 1 like
  BCL6 corepressor
  boule homolog, RNA binding protein
  bromodomain containing 7
  chromosome 1 open reading frame 94
  coordinator of PRMT5 and differentiation stimulator
  death effector domain containing 2
  developmental pluripotency-associated 3
  DMRT like family B with proline rich C-terminal 1
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 136 member A
  family with sequence similarity 168 member B
  F-box protein 7
  fibronectin type III domain containing 3B
  GATA zinc finger domain containing 1
  GLIS family zinc finger 2
  heterogeneous nuclear ribonucleoprotein F
  jumonji domain containing 4
  keratin associated protein 6-2
  mitogen-activated protein kinase 1 interacting protein 1 like
  musashi RNA binding protein 2
  nuclear assembly factor 1 ribonucleoprotein
  OTU deubiquitinase 4
  oxoeicosanoid receptor 1
  PHD finger protein 12
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing B1
  praja ring finger ubiquitin ligase 1
  presenilin associated rhomboid like
  Rhox homeobox family member 2
  ring finger and CCCH-type domains 2
  RIO kinase 1
  RNA binding fox-1 homolog 1
  RNA binding fox-1 homolog 2
  RNA binding motif protein 22
  RNA binding motif protein 23
  RNA binding motif protein 38
  RNA binding motif protein 42
  RNA binding protein, mRNA processing factor 2
  testis expressed 37
  toll interacting protein
  translocase of inner mitochondrial membrane 29
  tRNA methyltransferase 61A
  ubiquilin 2
  ubiquitin associated protein 2
  unk zinc finger
  VAC14 component of PIKFYVE complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.