PACRG, parkin coregulated

PACRG, parkin coregulated

• This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GLUP, HAK005771, PACRG2.1, PARK2CRG, parkin coregulated gene protein, PARK2 co-regulated, PARK2 coregulated, molecular chaperone/chaperonin-binding protein, parkin co-regulated gene protein,)
• NCBI Gene ID: 135138
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96M98
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

parkin coregulated interacts with:

• meiosis/spermiogenesis associated 1
  tubulin beta class I

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