PSMD4, proteasome 26S subunit, non-ATPase 4

PSMD4, proteasome 26S subunit, non-ATPase 4

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

• Gene Synonyms (26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit S5A, S5a/antisecretory factor protein, angiocidin, antisecretory factor 1, multiubiquitin chain-binding protein, proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5,)
• NCBI Gene ID: 5710
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55036
  UNIPROT ID#>>Q5VWC4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, non-ATPase 4 interacts with:

• actin, beta
  adenosylhomocysteinase like 1
  adenosylhomocysteinase like 2
  adhesion regulating molecule 1
  adhesion regulating molecule 1
  agrin
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  ankyrin repeat domain 13A
  ankyrin repeat domain 13B
  ATP binding cassette subfamily E member 1
  autophagy related 16 like 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRCA1 associated protein 1
  cell division cycle and apoptosis regulator 1
  centromere protein P
  coiled-coil domain containing 74B
  coiled-coil domain containing 92
  cullin 1
  cullin 2
  cullin 7
  CWC22 spliceosome associated protein homolog
  cysteinyl-tRNA synthetase 2, mitochondrial
  desumoylating isopeptidase 1
  dynactin subunit 2
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  elongator complex protein 1
  EPM2A glucan phosphatase, laforin
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  F-box protein 25
  F-box protein 6
  FKBP prolyl isomerase 8
  flotillin 1
  G protein nucleolar 3 like
  G protein subunit beta 5
  golgi to ER traffic protein 4
  H2A clustered histone 4
  H3 clustered histone 6
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of DNA binding 1, HLH protein
  insulin induced gene 2
  integrator complex subunit 5
  interferon induced transmembrane protein 3
  KDEL endoplasmic reticulum protein retention receptor 1
  kelch like ECH associated protein 1
  kinesin family binding protein
  L antigen family member 3
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  leucyl-tRNA synthetase 1
  LIM domain and actin binding 1
  mediator complex subunit 24
  mediator of DNA damage checkpoint 1
  membrane bound transcription factor peptidase, site 2
  methylphosphate capping enzyme
  microtubule associated protein 1 light chain 3 alpha
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein L57
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  NEDD4 like E3 ubiquitin protein ligase
  negative regulator of ubiquitin like proteins 1
  neuralized E3 ubiquitin protein ligase 4
  non-SMC condensin II complex subunit D3
  nuclear export mediator factor
  nuclear protein 1, transcriptional regulator
  nucleotide binding protein 2
  O-sialoglycoprotein endopeptidase
  phosphatase and tensin homolog
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 3
  protein disulfide isomerase family A member 4
  protein disulfide isomerase family A member 6
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type M
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RANBP2-type and C3HC4-type zinc finger containing 1
  Ras association domain family member 8
  RELA proto-oncogene, NF-kB subunit
  replication protein A1
  ribosomal protein L11
  ribosomal protein S12
  ring finger protein 11
  ring finger protein 4
  RTF1 homolog, Paf1/RNA polymerase II complex component
  S100 calcium binding protein P
  schwannomin interacting protein 1
  SEM1 26S proteasome complex subunit
  sequestosome 1
  siah E3 ubiquitin protein ligase 2
  single stranded DNA binding protein 1
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear RNA activating complex polypeptide 1
  snail family transcriptional repressor 1
  SprT-like N-terminal domain
  sterol regulatory element binding transcription factor 2
  STIP1 homology and U-box containing protein 1
  superoxide dismutase 1
  t-complex 11 like 1
  telomeric repeat binding factor 1
  thioredoxin interacting protein
  thioredoxin like 1
  thrombospondin 1
  TNF receptor superfamily member 21
  TNFAIP3 interacting protein 2
  TPD52 like 2
  transcription factor 3
  transglutaminase 2
  transmembrane protein 129, E3 ubiquitin ligase
  transmembrane protein 67
  tripartite motif containing 14
  tripartite motif containing 28
  tripartite motif containing 63
  tumor protein p53
  tumor protein p53 binding protein 1
  UBA domain containing 1
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin B
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin D
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  UBX domain protein 1
  unconventional SNARE in the ER 1
  valosin containing protein
  vir like m6A methyltransferase associated
  XPC complex subunit, DNA damage recognition and repair factor
  zinc finger protein 24
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.