PDIA4, protein disulfide isomerase family A member 4

PDIA4, protein disulfide isomerase family A member 4

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

• Gene Synonyms (protein disulfide-isomerase A4, ER protein 70, ER protein 72, endoplasmic reticulum resident protein 70, endoplasmic reticulum resident protein 72, protein disulfide isomerase related protein (calcium-binding protein, intestinal-related), protein disulfide isomerase-associated 4, testicular tissue protein Li 137, ERP70, ERP72, ERp-72,)
• NCBI Gene ID: 9601
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13667
  UNIPROT ID#>>A0A090N8Y2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein disulfide isomerase family A member 4 interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  anterior gradient 2, protein disulphide isomerase family member
  bone morphogenetic protein receptor, type 1A
  calreticulin 3
  centriolin
  coiled-coil domain containing 8
  cullin 7
  cytochrome c oxidase assembly factor COX14
  endoplasmic reticulum oxidoreductase 1 alpha
  endoplasmic reticulum oxidoreductase 1 beta
  ER degradation enhancing alpha-mannosidase like protein 3
  ER membrane protein complex subunit 3
  ER membrane protein complex subunit 7
  expressed sequence AI837181
  growth arrest and DNA damage inducible gamma
  HEXIM P-TEFb complex subunit 1
  isochorismatase domain containing 1
  keratin associated protein 10-8
  keratin associated protein 12-1
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  neudesin neurotrophic factor
  obscurin like cytoskeletal adaptor 1
  peptidyl-tRNA hydrolase 2
  plasminogen receptor with a C-terminal lysine
  proprotein convertase subtilisin/kexin type 9
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase receptor type U
  PTEN induced kinase 1
  pyridoxal phosphate binding protein
  serine/threonine kinase 26
  Shc SH2-domain binding protein 1
  sirtuin 7
  TatD DNase domain containing 1
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  twinfilin actin binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.