NEDD4L, NEDD4 like E3 ubiquitin protein ligase

NEDD4L, NEDD4 like E3 ubiquitin protein ligase

• This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

• Gene Synonyms (NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2, E3 ubiquitin-protein ligase NEDD4-like, HECT-type E3 ubiquitin transferase NED4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, ubiquitin-protein ligase Rsp5,)
• NCBI Gene ID: 23327
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z6K0
  UNIPROT ID#>>A0A024R2A4
  UNIPROT ID#>>A0A024R281
  UNIPROT ID#>>Q96PU5
  UNIPROT ID#>>B7Z2P9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NEDD4 like E3 ubiquitin protein ligase interacts with:

• 2,4-dienoyl-CoA reductase 2
  activation induced cytidine deaminase
  aminoacylase 3
  angiomotin
  angiomotin like 1
  apoptosis antagonizing transcription factor
  apurinic/apyrimidinic endodeoxyribonuclease 2
  ArfGAP with dual PH domains 2
  arrestin domain containing 1
  arrestin domain containing 3
  arrestin domain containing 4
  BBX high mobility group box domain containing
  calcium/calmodulin dependent protein kinase ID
  chromosome 7 open reading frame 50
  coiled-coil domain containing 8
  CREB regulated transcription coactivator 3
  CUE domain containing 1
  cytochrome b reductase 1
  cytochrome P450 family 26 subfamily B member 1
  DEAD-box helicase 54
  EGF containing fibulin extracellular matrix protein 2
  ER degradation enhancing alpha-mannosidase like protein 3
  F-box and leucine rich repeat protein 15
  golgin, RAB6 interacting
  hepatitis A virus cellular receptor 1
  hyperpolarization activated cyclic nucleotide gated potassium channel 1
  immunoglobulin like domain containing receptor 1
  mediator complex subunit 28
  misshapen like kinase 1
  mitogen-activated protein kinase kinase kinase 20
  MOB kinase activator 3A
  Nedd4 family interacting protein 1
  Nedd4 family interacting protein 1
  Nedd4 family interacting protein 2
  NEDD4 like E3 ubiquitin protein ligase
  NHP2 ribonucleoprotein
  nuclear speckle splicing regulatory protein 1
  nudix hydrolase 16 like 1
  occludin
  OTU deubiquitinase with linear linkage specificity like
  phosphatidylinositol 4-kinase type 2 alpha
  phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
  pleckstrin homology domain containing A4
  proline rich 16
  proline rich and Gla domain 3
  PYM homolog 1, exon junction complex associated factor
  RAN binding protein 10
  RAS like family 10 member B
  RAS like family 11 member B
  ring finger protein 11
  roundabout guidance receptor 3
  serine/threonine kinase 40
  serum/glucocorticoid regulated kinase family member 3
  solute carrier family 22 member 11
  sperm associated antigen 8
  SUMO specific peptidase 2
  TBC1 domain family member 7
  TNF receptor superfamily member 19
  toll interacting protein
  transcription elongation factor A like 2
  translation machinery associated 16 homolog
  transmembrane protein 171
  transmembrane protein 51
  transmembrane protein 52B
  transmembrane protein 92
  tripartite motif containing 41
  ubiquitin conjugating enzyme E2 J2
  vir like m6A methyltransferase associated
  WNK lysine deficient protein kinase 1
  WNK lysine deficient protein kinase 3
  WNK lysine deficient protein kinase 4
  WW domain binding protein 1
  WW domain binding protein 2
  zinc binding alcohol dehydrogenase domain containing 2
  zinc finger CCCH-type containing, antiviral 1 like
  zinc finger DHHC-type palmitoyltransferase 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.