- Gene Overview
- Interaction Network
- Sequence Verification
MAP3K20, mitogen-activated protein kinase kinase kinase 20
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This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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Gene Synonyms (mitogen-activated protein kinase kinase kinase 20, HCCS-4, MLK-like mitogen-activated protein triple kinase, ZAK1 homolog, leucine zipper and sterile-alpha motif kinase, human cervical cancer suppressor gene 4 protein, mitogen-activated protein kinase kinase kinase MLT, mixed lineage kinase 7, mixed lineage kinase with a leucine zipper and a sterile alpha motif, mixed lineage kinase-related kinase MRK-beta, sterile alpha motif and leucine zipper containing kinase AZK, AZK, CNM6, MLK7, MLT, MLTK, MLTKalpha, MLTKbeta, MRK, SFMMP, ZAK, mlklak, pk,)
- NCBI Gene ID:
51776
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>D4Q8H0
UNIPROT ID#>>Q9NYL2
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
mitogen-activated protein kinase kinase kinase 20 interacts with:
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this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
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