Skip Navigation Links Home » Resources » Gene Detail

PSME3, proteasome activator subunit 3

Matching ORF Clones

Request a Custom Clone

Don't see what you need?

Request My Custom Clone »
  • Gene Overview
  • Interaction Network
  • Sequence Verification

PSME3, proteasome activator subunit 3

  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

  • Gene Synonyms (proteasome activator complex subunit 3, 11S regulator complex gamma subunit, 11S regulator complex subunit gamma, Ki antigen, Ki nuclear autoantigen, PA28 gamma variant 5, REG gamma-3, activator of multicatalytic protease subunit 3, epididymis secretory protein Li 283, proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), proteasome activator 28 subunit gamma, proteasome activator 28-gamma, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA,)
  • NCBI Gene ID: 10197
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>V9HWJ8
    UNIPROT ID#>>B3KQ25
    UNIPROT ID#>>A0A024R203
    UNIPROT ID#>>Q6MZZ1
    UNIPROT ID#>>P61289
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome activator subunit 3 interacts with:

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

It appears that you have Javascript disabled. Our website requires Javascript to function correctly. For the best browsing experience, please enable Javascript.