SF3B2, splicing factor 3b subunit 2

SF3B2, splicing factor 3b subunit 2

• This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]

• Gene Synonyms (Cus1, SAP145, SF3B145, SF3b1, SF3b150, splicing factor 3B subunit 2, SAP 145, pre-mRNA splicing factor SF3b 145 kDa subunit, spliceosome associated protein 145, splicing factor 3b, subunit 2, 145kD, splicing factor 3b, subunit 2, 145kDa,)
• NCBI Gene ID: 10992
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13435
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

splicing factor 3b subunit 2 interacts with:

• AAR2 splicing factor
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  anaphase promoting complex subunit 16
  basic leucine zipper transcription factor, ATF-like 3
  cell division cycle associated 5
  checkpoint kinase 2
  chromosome 7 open reading frame 25
  chromosome 8 open reading frame 33
  coiled-coil domain containing 97
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  cullin associated and neddylation dissociated 1
  decapping enzyme, scavenger
  developmental pluripotency-associated 3
  DNA topoisomerase II binding protein 1
  Ecm29 proteasome adaptor and scaffold
  elongin C
  F-box and WD repeat domain containing 11
  F-box protein 6
  forkhead box Q1
  FRA10A associated CGG repeat 1
  glutamate rich WD repeat containing 1
  GRB10 interacting GYF protein 2
  histone deacetylase 11
  jun B proto-oncogene
  kinesin family member 20B
  La ribonucleoprotein 7, transcriptional regulator
  lin-28 homolog A
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  lysine demethylase 1A
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  MIS12 kinetochore complex component
  nei like DNA glycosylase 3
  NHL repeat containing 2
  nucleolar protein 12
  obscurin like cytoskeletal adaptor 1
  PHD finger protein 5A
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 40 homolog A
  proline rich 11
  protein phosphatase 4 regulatory subunit 2
  PTEN induced kinase 1
  pyrin and HIN domain family member 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  RIO kinase 1
  RNA binding motif protein 11
  RNA binding motif protein 17
  RNA binding motif protein 42
  RNA binding motif protein X-linked
  serine/arginine repetitive matrix 2
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small integral membrane protein 20
  small nuclear ribonucleoprotein U5 subunit 200
  SNW domain containing 1
  spindle apparatus coiled-coil protein 1
  splicing factor 3a, subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor 3b subunit 5
  splicing factor 3b subunit 6
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  target of EGR1, exonuclease
  TEPSIN adaptor related protein complex 4 accessory protein
  terminal nucleotidyltransferase 4B
  tetratricopeptide repeat domain 14
  translocase of inner mitochondrial membrane 13
  transmembrane p24 trafficking protein 9
  tropomodulin 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  vir like m6A methyltransferase associated
  VPS50 subunit of EARP/GARPII complex
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  XPA binding protein 2
  zinc finger CCCH-type containing 8
  zinc finger CCHC-type and RNA binding motif containing 1
  zinc finger CCHC-type containing 10
  zinc finger protein 830

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