DCPS, decapping enzyme, scavenger

DCPS, decapping enzyme, scavenger

• This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]

• Gene Synonyms (m7GpppX diphosphatase, 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase, decapping scavenger enzyme, epididymis secretory sperm binding protein, heat shock-like protein 1, hint-related 7meGMP-directed hydrolase, histidine triad nucleotide-binding protein 5, histidine triad protein member 5, homolog of C. elegans 7meGMP-directed hydrolase dcs-1, mRNA decapping enzyme, scavenger mRNA-decapping enzyme DcpS, ARS, DCS1, HINT-5, HINT5, HSL1, HSPC015,)
• NCBI Gene ID: 28960
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96C86
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

decapping enzyme, scavenger interacts with:

• 5'-nucleotidase domain containing 3
  actin beta like 2
  acyl-CoA dehydrogenase family member 9
  AHNAK nucleoprotein
  anaphase promoting complex subunit 4
  ATP synthase membrane subunit DAPIT
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  ATPase family AAA domain containing 3A
  BARX homeobox 1
  biogenesis of ribosomes BRX1
  bromodomain adjacent to zinc finger domain 2B
  calcium/calmodulin dependent protein kinase ID
  cell division cycle 73
  centromere protein V
  centrosomal protein 128
  chromosome 6 open reading frame 132
  chromosome alignment maintaining phosphoprotein 1
  coiled-coil domain containing 102A
  cyclic GMP-AMP synthase
  DEAD-box helicase 54
  decapping enzyme, scavenger
  deoxynucleotidyltransferase terminal interacting protein 2
  dermcidin
  exosome component 6
  family with sequence similarity 207 member A
  fermitin family member 3
  filaggrin family member 2
  fizzy and cell division cycle 20 related 1
  FtsJ RNA 2'-O-methyltransferase 3
  GINS complex subunit 3
  GINS complex subunit 4
  H2A clustered histone 19
  H2A.Z variant histone 2
  H2B clustered histone 18
  H3 clustered histone 13
  H6 family homeobox 3
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein U like 2
  IMP U3 small nucleolar ribonucleoprotein 3
  integrator complex subunit 3
  lactamase beta
  lamin B2
  LAS1 like ribosome biogenesis factor
  leucine rich repeat containing 59
  leucine rich repeats and calponin homology domain containing 3
  ligand dependent nuclear receptor interacting factor 1
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LUC7 like 2, pre-mRNA splicing factor
  MAK16 homolog
  MIS18 binding protein 1
  mitochondrial ribosomal protein L50
  myosin IG
  MYST/Esa1 associated factor 6
  N-acetyltransferase 10
  NOP10 ribonucleoprotein
  NOP16 nucleolar protein
  NOP2/Sun RNA methyltransferase 2
  NOP58 ribonucleoprotein
  nuclear receptor coactivator 5
  nuclear transport factor 2 like export factor 1
  nucleolar complex associated 4 homolog
  nucleolar pre-rRNA processing protein NIP7
  nucleolar protein 10
  nucleolar protein 6
  nucleolar protein interacting with the FHA domain of MKI67
  nucleoporin 107
  nucleoporin 133
  nucleoporin 85
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphoinositide-3-kinase adaptor protein 1
  phosphopantothenoylcysteine decarboxylase
  pleckstrin homology domain interacting protein
  poly(ADP-ribose) polymerase family member 14
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 40 homolog A
  refilin B
  regulation of nuclear pre-mRNA domain containing 1B
  remodeling and spacing factor 1
  ribosome production factor 1 homolog
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 22
  RNA binding motif protein 25
  RNA polymerase I subunit B
  RNA polymerase I subunit E
  SAFB like transcription modulator
  SEH1 like nucleoporin
  spectrin repeat containing nuclear envelope family member 3
  spermatogenesis associated 5
  splicing factor 3b subunit 6
  SPOUT domain containing methyltransferase 1
  structural maintenance of chromosomes 6
  SUMO specific peptidase 1
  TAO kinase 3
  thioredoxin related transmembrane protein 1
  THO complex 2
  THO complex 6
  tRNA methyltransferase 61B
  UTP11 small subunit processome component
  UTP15 small subunit processome component
  UTP3 small subunit processome component
  UTP4 small subunit processome component
  WD repeat domain 55
  WD repeat domain 74
  WD repeat domain 75
  zinc finger protein 740

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