TMX1, thioredoxin related transmembrane protein 1

TMX1, thioredoxin related transmembrane protein 1

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

• Gene Synonyms (thioredoxin-related transmembrane protein 1, protein disulfide isomerase family A, member 11, thioredoxin domain containing 1, thioredoxin domain-containing protein 1, transmembrane Trx-related protein, PDIA11, TMX, TXNDC, TXNDC1,)
• NCBI Gene ID: 81542
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H3N1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin related transmembrane protein 1 interacts with:

• calreticulin 3
  cysteine rich transmembrane module containing 1
  EvC ciliary complex subunit 2
  GTPase, IMAP family member 1
  immunoglobulin superfamily member 8
  leucine rich repeat kinase 2
  LHFPL tetraspan subfamily member 5
  LY6/PLAUR domain containing 6
  rhomboid domain containing 1
  synoviolin 1
  transmembrane protein 17
  transmembrane protein 179B
  zona pellucida like domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.