NSUN2, NOP2/Sun RNA methyltransferase 2

NSUN2, NOP2/Sun RNA methyltransferase 2

• This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]

• Gene Synonyms (RNA cytosine C(5)-methyltransferase NSUN2, 5-methycytoisine methyltransferase, Myc-induced SUN-domain-containing protein, NOL1/NOP2/Sun domain family, member 2, NOP2/Sun RNA methyltransferase family member 2, NOP2/Sun domain family, member 2, mRNA cytosine C(5)-methyltransferase, myc-induced SUN domain-containing protein, substrate of AIM1/Aurora kinase B, tRNA (cytosine(34)-C(5))-methyltransferase, tRNA (cytosine-5-)-methyltransferase NSUN2, tRNA cytosine C(5)-methyltransferase, tRNA methyltransferase 4 homolog, MISU, MRT5, SAKI, TRM4,)
• NCBI Gene ID: 54888
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q08J23
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NOP2/Sun RNA methyltransferase 2 interacts with:

• BCL2 like 14
  carnosine dipeptidase 2
  centrosomal protein 78
  coiled-coil domain containing 8
  cullin associated and neddylation dissociated 1
  elongation factor like GTPase 1
  exportin 5
  glutamate rich WD repeat containing 1
  integrin alpha FG-GAP repeat containing 1
  lebercilin LCA5
  limb development membrane protein 1 like
  lin-7 homolog C, crumbs cell polarity complex component
  methyltransferase like 3
  neutrophil cytosolic factor 1
  O-sialoglycoprotein endopeptidase
  pantothenate kinase 4 (inactive)
  partner of NOB1 homolog
  phosphatase and actin regulator 3
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proline rich 20E
  pseudouridine synthase 1
  pyrin and HIN domain family member 1
  ribosomal protein L35
  RIO kinase 1
  signal recognition particle 72
  TP53 regulating kinase
  tRNA-histidine guanylyltransferase 1 like
  tubulin, gamma 1
  UDP-glucose glycoprotein glucosyltransferase 1
  zinc finger FYVE-type containing 21
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.