KDM1A, lysine demethylase 1A

KDM1A, lysine demethylase 1A

• This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

• Gene Synonyms (AOF2, BHC110, CPRF, KDM1, LSD1, lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A, amine oxidase (flavin containing) domain 2, flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1A, lysine-specific histone demethylase 1,)
• NCBI Gene ID: 23028
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60341
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine demethylase 1A interacts with:

• activating signal cointegrator 1 complex subunit 2
  ankyrin repeat and EF-hand domain containing 1
  ankyrin repeat and SOCS box containing 10
  ankyrin repeat and SOCS box containing 3
  ankyrin repeat domain 23
  ariadne RBR E3 ubiquitin protein ligase 1
  arrestin domain containing 1
  autophagy related 16 like 1
  B9 domain containing 2
  cancer antigen 1
  caspase recruitment domain family member 10
  caveolae associated protein 1
  cell division cycle associated 4
  cell division cycle associated 5
  centromere protein Q
  centrosomal protein 70
  centrosomal protein 76
  cereblon
  chromosome 18 open reading frame 54
  chromosome 4 open reading frame 17
  chromosome 8 open reading frame 48
  chromosome 8 open reading frame 74
  cilia and flagella associated protein 100
  coiled-coil domain containing 121
  coiled-coil domain containing 14
  coiled-coil domain containing 151
  coiled-coil domain containing 172
  coiled-coil domain containing 33
  coiled-coil domain containing 74A
  coiled-coil domain containing 74B
  coiled-coil domain containing 90B
  coiled-coil domain containing 93
  cytokine receptor like factor 3
  DBF4 zinc finger B
  deoxynucleotidyltransferase terminal interacting protein 1
  docking protein 4
  dynein axonemal assembly factor 4
  dynein light chain LC8-type 1
  E1A binding protein p400
  egl-9 family hypoxia inducible factor 3
  elongation factor 1 homolog
  establishment of sister chromatid cohesion N-acetyltransferase 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  exocyst complex component 1
  exocyst complex component 7
  FAM161 centrosomal protein A
  family with sequence similarity 204 member A
  family with sequence similarity 9 member A
  F-box and WD repeat domain containing 7
  fidgetin like 1
  FYVE and coiled-coil domain autophagy adaptor 1
  GA binding protein transcription factor subunit beta 2
  glutathione S-transferase C-terminal domain containing
  glyoxylate reductase 1 homolog
  golgin A6 family member A
  G-patch domain containing 2 like
  GRIP and coiled-coil domain containing 1
  GRIP1 associated protein 1
  Gse1 coiled-coil protein
  GTP binding protein 2
  H3 clustered histone 14
  H3.5 histone
  HAUS augmin like complex subunit 1
  HAUS augmin like complex subunit 3
  HAUS augmin like complex subunit 6
  histone deacetylase 11
  hypoxia inducible factor 1 subunit alpha inhibitor
  IKBKB interacting protein
  integrator complex subunit 2
  integrin subunit beta 3 binding protein
  intersectin 2
  KASH domain containing 5
  KAT8 regulatory NSL complex subunit 1
  kelch domain containing 4
  keratin 222
  keratin 39
  keratin 40
  kinesin light chain 3
  Kruppel like factor 3
  L3MBTL histone methyl-lysine binding protein 3
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leukocyte receptor cluster member 8
  lysine demethylase 1A
  lysyl oxidase like 4
  meiosis specific nuclear structural 1
  membrane bound transcription factor peptidase, site 2
  metastasis associated 1 family member 3
  methyl-CpG binding domain protein 3
  methyltransferase like 18
  methyltransferase like 21C
  methyltransferase like 27
  microcephalin 1
  mitochondrial tRNA translation optimization 1
  modulator of VRAC current 1
  myosin regulatory light chain interacting protein
  myotubularin related protein 9
  NBPF member 15
  NBPF member 26
  nitric oxide synthase trafficking
  N-terminal EF-hand calcium binding protein 2
  nuclear receptor binding factor 2
  obscurin like cytoskeletal adaptor 1
  orofacial cleft 1 candidate 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  outer mitochondrial membrane lipid metabolism regulator OPA3
  PBX homeobox 4
  PHD finger protein 19
  PHD finger protein 20 like 1
  PHD finger protein 21A
  PHD finger protein 8
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family B member 3
  PRAME nuclear receptor transcriptional regulator
  proline, glutamate and leucine rich protein 1
  Ras association domain family member 3
  regulation of nuclear pre-mRNA domain containing 1A
  required for meiotic nuclear division 5 homolog A
  REST corepressor 1
  REST corepressor 3
  Rho GTPase activating protein 15
  ring finger protein 168
  RIO kinase 1
  RPGRIP1 like
  Scm like with four mbt domains 1
  secretion regulating guanine nucleotide exchange factor
  septin 6
  SH3 domain containing GRB2 like, endophilin B2
  SIN3 transcription regulator family member A
  sirtuin 7
  sodium channel and clathrin linker 1
  sorting nexin 15
  spermatogenesis associated 22
  spermatogenesis associated 24
  spermatogenic leucine zipper 1
  spindle and centriole associated protein 1
  splA/ryanodine receptor domain and SOCS box containing 1
  SSX family member 2 interacting protein
  sterile alpha motif domain containing 3
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  syntaxin 19
  TBL1X receptor 1
  testis expressed 35
  testis expressed 9
  tetratricopeptide repeat domain 23
  tetratricopeptide repeat domain 33
  THO complex 2
  toll like receptor 9
  translocase of inner mitochondrial membrane 50
  transmembrane protein 266
  tripartite motif containing 39
  tripartite motif containing 54
  TSSK6 activating cochaperone
  tubulin epsilon and delta complex 2
  tuftelin interacting protein 11
  ubiquitin associated and SH3 domain containing B
  ubiquitin C-terminal hydrolase L5
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 22
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 38
  UFM1 specific ligase 1
  unk like zinc finger
  unk zinc finger
  vir like m6A methyltransferase associated
  VPS11 core subunit of CORVET and HOPS complexes
  VPS37A subunit of ESCRT-I
  VPS37B subunit of ESCRT-I
  VPS50 subunit of EARP/GARPII complex
  VPS53 subunit of GARP complex
  WASH complex subunit 3
  WD repeat domain 83
  Z-DNA binding protein 1
  ZFP28 zinc finger protein
  zinc finger and SCAN domain containing 5A
  zinc finger CCHC-type containing 17
  zinc finger HIT-type containing 6
  zinc finger protein 280A
  zinc finger protein 333
  zinc finger protein 436
  zinc finger protein 451
  zinc finger protein 480
  zinc finger protein 581
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 641
  zinc finger protein 71
  zinc finger protein 829

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.