UHRF1, ubiquitin like with PHD and ring finger domains 1

UHRF1, ubiquitin like with PHD and ring finger domains 1

• This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

• Gene Synonyms (E3 ubiquitin-protein ligase UHRF1, RING finger protein 106, RING-type E3 ubiquitin transferase UHRF1, inverted CCAAT box-binding protein of 90 kDa, nuclear phosphoprotein 95, nuclear protein 95, nuclear zinc finger protein Np95, transcription factor ICBP90, ubiquitin-like PHD and RING finger domain-containing protein 1, ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95,)
• NCBI Gene ID: 29128
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WVR3
  UNIPROT ID#>>Q96T88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin like with PHD and ring finger domains 1 interacts with:

• coiled-coil domain containing 8
  developmental pluripotency-associated 3
  essential meiotic structure-specific endonuclease 1
  F-box protein 38
  H3 clustered histone 13
  H3 clustered histone 14
  H3 clustered histone 15
  mitochondrial rRNA methyltransferase 3
  MUS81 structure-specific endonuclease subunit
  pleckstrin homology domain containing A4
  polycomb group ring finger 1
  PR/SET domain 16
  RAD18 E3 ubiquitin protein ligase
  remodeling and spacing factor 1
  ribosomal protein L35
  ribosome binding protein 1
  SET domain containing 7, histone lysine methyltransferase
  signal recognition particle 72
  transient receptor potential cation channel subfamily V member 5
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  UHRF1 binding protein 1
  WD repeat containing antisense to TP53
  WD repeat domain, phosphoinositide interacting 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.