PRAME, PRAME nuclear receptor transcriptional regulator

PRAME, PRAME nuclear receptor transcriptional regulator

• This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Gene Synonyms (melanoma antigen preferentially expressed in tumors, Opa-interacting protein OIP4, cancer/testis antigen 130, opa-interacting protein 4, preferentially expressed antigen in melanoma, preferentially expressed antigen of melanoma, CT130, MAPE, OIP-4, OIP4,)
• NCBI Gene ID: 23532
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z7K8
  UNIPROT ID#>>B7Z986
  UNIPROT ID#>>P78395
  UNIPROT ID#>>B7ZAT0
  UNIPROT ID#>>A0A024R1E6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PRAME nuclear receptor transcriptional regulator interacts with:

• antizyme inhibitor 2
  coiled-coil domain containing 28B
  fascin actin-bundling protein 3
  F-box and leucine rich repeat protein 12
  F-box protein 7
  glutamine amidotransferase like class 1 domain containing 1
  H4 histone 16
  intraflagellar transport 81
  methyltransferase like 14
  methyltransferase like 3
  MTOR associated protein, LST8 homolog
  nucleolar protein 11
  O-sialoglycoprotein endopeptidase
  PRAME nuclear receptor transcriptional regulator
  queuine tRNA-ribosyltransferase catalytic subunit 1
  sirtuin 6
  TP53 regulating kinase
  TP53RK binding protein
  zinc finger protein 408
  zinc finger protein 562

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.