TXNIP, thioredoxin interacting protein

TXNIP, thioredoxin interacting protein

• This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Gene Synonyms (ARRDC6, EST01027, HHCPA78, THIF, VDUP1, thioredoxin-interacting protein, thioredoxin binding protein 2, upregulated by 1,25-dihydroxyvitamin D-3, vitamin D3 up-regulated protein 1,)
• NCBI Gene ID: 10628
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H3M7
  UNIPROT ID#>>A0A024R4B7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin interacting protein interacts with:

• activity dependent neuroprotector homeobox
  adaptor-related protein complex 2, alpha 2 subunit
  AHNAK nucleoprotein
  ATPase family AAA domain containing 3A
  cell division cycle 73
  chromosome X open reading frame 56
  clathrin, heavy polypeptide (Hc)
  COP9 signalosome subunit 5
  DDB1 and CUL4 associated factor 16
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  DNA damage inducible transcript 4
  ecdysoneless cell cycle regulator
  epidermal growth factor receptor pathway substrate 15 like 1
  family with sequence similarity 91 member A1
  GATA zinc finger domain containing 2B
  GTP binding protein 4
  heat shock protein family A (Hsp70) member 4 like
  itchy E3 ubiquitin protein ligase
  jumonji domain containing 1C
  kelch repeat and BTB domain containing 6
  kelch repeat and BTB domain containing 7
  lysine demethylase 1A
  MAGE family member D2
  methyl-CpG binding domain protein 3
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  MYC binding protein 2
  neuroligin 3
  NLR family pyrin domain containing 3
  NOP58 ribonucleoprotein
  protein phosphatase 6 regulatory subunit 3
  RAD18 E3 ubiquitin protein ligase
  repulsive guidance molecule BMP co-receptor a
  RuvB like AAA ATPase 2
  SAP30 binding protein
  SMAD specific E3 ubiquitin protein ligase 2
  stress induced phosphoprotein 1
  thioredoxin 2
  thioredoxin interacting protein
  ubiquitin conjugating enzyme E2 O
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  YEATS domain containing 2
  zinc finger and BTB domain containing 32
  zinc finger CCCH-type containing, antiviral 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.