LAGE3, L antigen family member 3

LAGE3, L antigen family member 3

• This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EKC/KEOPS complex subunit LAGE3, protein ESO-3, CVG5, DXS9879E, DXS9951E, ESO3, GAMOS2, ITBA2, Pcc1,)
• NCBI Gene ID: 8270
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14657
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

L antigen family member 3 interacts with:

• adenosylhomocysteinase like 1
  A-kinase anchoring protein 8 like
  chaperonin containing TCP1 subunit 7
  coiled-coil domain containing 28B
  cullin 2
  cullin associated and neddylation dissociated 1
  cysteine rich tail 1
  egl-9 family hypoxia inducible factor 3
  GINS complex subunit 4
  golgin A6 family like 9
  GON7 subunit of KEOPS complex
  heat shock transcription factor 2 binding protein
  hydroxylysine kinase
  keratin 40
  keratin associated protein 10-8
  keratin associated protein 6-3
  MAGE family member D2
  midline 2
  mirror-image polydactyly 1
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  NDRG family member 3
  nucleoporin 43
  opioid growth factor receptor
  O-sialoglycoprotein endopeptidase
  O-sialoglycoprotein endopeptidase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing J1
  PNMA family member 1
  POP7 homolog, ribonuclease P/MRP subunit
  PRAME nuclear receptor transcriptional regulator
  protein tyrosine phosphatase non-receptor type 23
  pumilio RNA binding family member 1
  ring finger protein 114
  ring finger protein 214
  RNA polymerase II associated protein 1
  selenophosphate synthetase 2
  target of myb1 like 2 membrane trafficking protein
  TP53 regulating kinase
  TP53RK binding protein
  ubiquitin specific peptidase 34
  valosin containing protein lysine methyltransferase
  VPS37C subunit of ESCRT-I
  zinc finger FYVE-type containing 19
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.