SPRTN, SprT-like N-terminal domain

SPRTN, SprT-like N-terminal domain

• The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

• Gene Synonyms (sprT-like domain-containing protein Spartan, DNA damage protein targeting VCP, DNA damage-targeting VCP (p97) adaptor, zinc finger RAD18 domain-containing protein, C1orf124, DVC1, PRO4323, spartan,)
• NCBI Gene ID: 83932
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H040
  UNIPROT ID#>>A0A024R3U2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SprT-like N-terminal domain interacts with:

• H2B clustered histone 12
  H2B clustered histone 18
  lactamase beta
  potassium channel tetramerization domain containing 13
  RAN binding protein 3 like
  SLX4 structure-specific endonuclease subunit
  tubulin beta 6 class V
  XK related X-linked

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.