RELA, RELA proto-oncogene, NF-kB subunit

RELA, RELA proto-oncogene, NF-kB subunit

• NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

• Gene Synonyms (transcription factor p65, NF-kappa-B p65delta3, NF-kappa-B transcription factor p65, nuclear factor NF-kappa-B p65 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, v-rel avian reticuloendotheliosis viral oncogene homolog A, v-rel reticuloendotheliosis viral oncogene homolog A, CMCU, NFKB3, p65,)
• NCBI Gene ID: 5970
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087X0W8
  UNIPROT ID#>>Q04206
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RELA proto-oncogene, NF-kB subunit interacts with:

• adenosylhomocysteinase like 1
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  A-kinase interacting protein 1
  ankyrin repeat and SOCS box containing 9
  apoptosis antagonizing transcription factor
  argonaute RISC component 1
  aurora kinase A
  basic leucine zipper ATF-like transcription factor 2
  beclin 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRMS1 transcriptional repressor and anoikis regulator
  BTG3 associated nuclear protein
  casein kinase 1 gamma 1
  C-C motif chemokine ligand 5
  CCAAT enhancer binding protein zeta
  centromere protein J
  checkpoint with forkhead and ring finger domains
  coactivator associated arginine methyltransferase 1
  COMM domain containing 10
  COMM domain containing 2
  COMM domain containing 4
  COMM domain containing 5
  COMM domain containing 6
  COMM domain containing 7
  COMM domain containing 8
  copper metabolism domain containing 1
  cullin 2
  cyclin and CBS domain divalent metal cation transport mediator 3
  dermcidin
  DIS3 like 3'-5' exoribonuclease 2
  DNA methyltransferase 3 like
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B6
  double PHD fingers 1
  double PHD fingers 2
  double PHD fingers 3
  ECSIT signaling integrator
  egl-9 family hypoxia inducible factor 3
  ETHE1 persulfide dioxygenase
  euchromatic histone lysine methyltransferase 1
  exportin 1
  Fas associated factor 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  FKBP prolyl isomerase 11
  forkhead box P3
  gigaxonin
  GLIS family zinc finger 1
  glypican 6
  golgi associated PDZ and coiled-coil motif containing
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HEXIM P-TEFb complex subunit 1
  high mobility group AT-hook 2
  histone deacetylase 1
  histone deacetylase 3
  histone deacetylase 6
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  huntingtin interacting protein K
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of growth family member 4
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  integrin subunit beta 3 binding protein
  interferon regulatory factor 9
  interleukin 1 receptor associated kinase 1 binding protein 1
  IQ motif containing GTPase activating protein 2
  karyopherin subunit alpha 6
  kelch like ECH associated protein 1
  Kruppel like factor 4
  large tumor suppressor kinase 2
  leucine rich repeat containing 66
  lysine acetyltransferase 2B
  lysine acetyltransferase 5
  lysine demethylase 1A
  lysine demethylase 2A
  MAF bZIP transcription factor K
  makorin ring finger protein 2
  mediator complex subunit 15
  mediator complex subunit 23
  mediator complex subunit 7
  metadherin
  mitogen-activated protein kinase kinase kinase 7
  MKS transition zone complex subunit 1
  mono-ADP ribosylhydrolase 1
  MYB binding protein 1a
  myotrophin
  neutrophil cytosolic factor 1
  NFKB repressing factor
  NK2 homeobox 1
  N-myc and STAT interactor
  nuclear FMR1 interacting protein 2
  nuclear receptor binding SET domain protein 1
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor corepressor 2
  O-linked N-acetylglucosamine (GlcNAc) transferase
  PDZ and LIM domain 2
  PHD finger protein 10
  piwi like RNA-mediated gene silencing 4
  POTE ankyrin domain family member E
  POTE ankyrin domain family member J
  POU class 6 homeobox 2
  PPARG coactivator 1 alpha
  programmed cell death 11
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 3
  protein phosphatase 1 regulatory subunit 13 like
  PTOV1 extended AT-hook containing adaptor protein
  RALBP1 associated Eps domain containing 2
  Ras association domain family member 1
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  replication factor C subunit 1
  reticulon 4 interacting protein 1
  retinoid X receptor alpha
  REV1 DNA directed polymerase
  ribonuclease A family member 1, pancreatic
  ribosomal protein L13
  ribosomal protein L23
  ribosomal protein S3
  ribosomal protein S6 kinase A5
  ring finger protein 2
  ring finger protein 25
  RIO kinase 2
  sequestosome 1
  serine and arginine rich splicing factor 7
  serum response factor
  SET domain containing 6, protein lysine methyltransferase
  SET domain containing 7, histone lysine methyltransferase
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 6
  Sin3A associated protein 18
  sirtuin 1
  sirtuin 5
  sirtuin 6
  slingshot protein phosphatase 3
  Smad nuclear interacting protein 1
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein U1 subunit 70
  snail family transcriptional repressor 1
  solute carrier family 1 member 2
  sorbitol dehydrogenase
  sorting nexin 27
  Sp1 transcription factor
  Sp3 transcription factor
  SPATA31 subfamily A member 3
  spermidine/spermine N1-acetyltransferase 1
  STIP1 homology and U-box containing protein 1
  sulfite oxidase
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  suppressor of cytokine signaling 6
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  TANK binding kinase 1
  TATA-box binding protein
  TATA-box binding protein associated factor 1
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 4b
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 9
  TEA domain transcription factor 4
  telomerase reverse transcriptase
  thioredoxin 2
  thioredoxin interacting protein
  thymidine kinase 1
  thyroid hormone receptor interactor 4
  titin-cap
  TLE family member 1, transcriptional corepressor
  TNFAIP3 interacting protein 2
  transcription factor 4
  transcription factor AP-2 alpha
  transducin beta like 1 X-linked
  transglutaminase 2
  translocase of inner mitochondrial membrane 13
  translocase of inner mitochondrial membrane 8 homolog B
  tribbles pseudokinase 3
  tumor protein p53
  tumor protein p53 binding protein 1
  tumor protein p53 binding protein 2
  tumor protein p63
  twist family bHLH transcription factor 1
  ubiquilin 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 H
  ubiquitin conjugating enzyme E2 L3
  ubiquitin specific peptidase 31
  ubiquitin specific peptidase 48
  ubiquitin specific peptidase 7
  unc-5 family C-terminal like
  upstream transcription factor 2, c-fos interacting
  vitamin D receptor
  WASP actin nucleation promoting factor
  WD repeat domain 26
  WD repeat domain 61
  ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
  zinc finger and BTB domain containing 33
  zinc finger and BTB domain containing 7A
  zinc finger and BTB domain containing 7B
  zinc fingers and homeoboxes 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.