TAF6, TATA-box binding protein associated factor 6

TAF6, TATA-box binding protein associated factor 6

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

• Gene Synonyms (transcription initiation factor TFIID subunit 6, RNA polymerase II TBP-associated factor subunit E, TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa, TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD, transcription initiation factor TFIID 70 kDa subunit, ALYUS, MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85,)
• NCBI Gene ID: 6878
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A4D299
  UNIPROT ID#>>P49848
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 6 interacts with:

• autophagy related 16 like 1
  biorientation of chromosomes in cell division 1 like 1
  BTG3 associated nuclear protein
  cell division cycle 26
  dynactin 3
  H2A clustered histone 4
  H3 clustered histone 1
  H3.4 histone
  H4 clustered histone 1
  mediator complex subunit 26
  methyl-CpG binding domain protein 3
  nuclear receptor corepressor 1
  nuclear receptor subfamily 1 group D member 2
  nuclear receptor subfamily 2 group C member 2
  PIH1 domain containing 2
  protein phosphatase 1 regulatory subunit 21
  SAMM50 sorting and assembly machinery component
  SET domain containing 7, histone lysine methyltransferase
  SH3 domain containing kinase binding protein 1
  SIN3 transcription regulator family member A
  Sin3A associated protein 30
  TATA-box binding protein
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9
  TATA-box binding protein associated factor 9b
  TATA-box binding protein like 1
  transformation/transcription domain associated protein
  tumor protein p53
  ubiquitin specific peptidase 37
  UFM1 specific ligase 1
  upstream transcription factor 1

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