USF1, upstream transcription factor 1

USF1, upstream transcription factor 1

• This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

• Gene Synonyms (upstream stimulatory factor 1, class B basic helix-loop-helix protein 11, major late transcription factor 1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11,)
• NCBI Gene ID: 7391
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22415
  UNIPROT ID#>>A0A0S2Z4U5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

upstream transcription factor 1 interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 12
  AFG3 like matrix AAA peptidase subunit 2
  ASH2 like, histone lysine methyltransferase complex subunit
  ATP synthase peripheral stalk subunit d
  BAG cochaperone 3
  basic leucine zipper ATF-like transcription factor 3
  chromodomain helicase DNA binding protein 8
  dicer 1, ribonuclease III
  essential meiotic structure-specific endonuclease 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  F-box protein 7
  FOS like 1, AP-1 transcription factor subunit
  GTF2I repeat domain containing 1
  H4 clustered histone 1
  homeobox and leucine zipper encoding
  kinesin family member 21B
  leucine aminopeptidase 3
  lysine acetyltransferase 2B
  malonyl-CoA-acyl carrier protein transacylase
  MAP3K7 C-terminal like
  PCF11 cleavage and polyadenylation factor subunit
  pleckstrin homology and FYVE domain containing 2
  plexin A3
  PPARG coactivator 1 alpha
  RNA terminal phosphate cyclase like 1
  SET domain containing 1A, histone lysine methyltransferase
  SNW domain containing 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  TAO kinase 2
  transcription factor like 5
  transformation/transcription domain associated protein
  tripartite motif containing 11
  tRNA methyltransferase 13 homolog
  ubiquitin protein ligase E3 component n-recognin 4
  upstream transcription factor 1
  upstream transcription factor 2, c-fos interacting
  WD repeat domain 5
  X-ray repair cross complementing 5
  zinc finger protein 644

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.