DICER1, dicer 1, ribonuclease III

DICER1, dicer 1, ribonuclease III

• This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

• Gene Synonyms (endoribonuclease Dicer, Dicer1, Dcr-1 homolog, dicer 1, double-stranded RNA-specific endoribonuclease, dicer 1, ribonuclease type III, helicase MOI, helicase with RNAse motif, DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2,)
• NCBI Gene ID: 23405
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UPY3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dicer 1, ribonuclease III interacts with:

• actin related protein 5
  anaphase promoting complex subunit 13
  argonaute RISC catalytic component 2
  argonaute RISC catalytic component 3
  argonaute RISC catalytic subunit 2
  argonaute RISC component 1
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 1
  carboxypeptidase A6
  centromere protein M
  centrosomal protein 19
  cilia and flagella associated protein 20
  coiled-coil domain containing 8
  DExH-box helicase 58
  dicer 1, ribonuclease III
  dual specificity phosphatase 13
  dual specificity phosphatase 15
  dual specificity phosphatase 26
  egl-9 family hypoxia inducible factor 3
  F-box and leucine rich repeat protein 14
  forkhead box D4 like 6
  G protein nucleolar 2
  gem nuclear organelle associated protein 4
  GTP binding protein 4
  histone deacetylase 11
  INO80 complex subunit B
  IQ motif containing N
  mediator of cell motility 1
  mitochondrial fission regulator 2
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Myb like, SWIRM and MPN domains 1
  NOC3 like DNA replication regulator
  piwi like RNA-mediated gene silencing 2
  piwi like RNA-mediated gene silencing 3
  piwi like RNA-mediated gene silencing 4
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  protein tyrosine phosphatase mitochondrial 1
  pyrin and HIN domain family member 1
  SCY1 like pseudokinase 1
  sirtuin 7
  small glutamine rich tetratricopeptide repeat containing beta
  spermatid perinuclear RNA binding protein
  staufen double-stranded RNA binding protein 2
  translocase of inner mitochondrial membrane 13
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tripartite motif containing 41
  tripartite motif containing 71
  tRNA methyltransferase 2 homolog A
  ubiquitin specific peptidase 49
  vir like m6A methyltransferase associated
  zinc finger matrin-type 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.