GEMIN4, gem nuclear organelle associated protein 4

GEMIN4, gem nuclear organelle associated protein 4

• The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (gem-associated protein 4, HCC-associated protein 1, component of gems 4, gemin-4, HC56, HCAP1, HHRF-1, NEDMCR, p97,)
• NCBI Gene ID: 50628
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P57678
  UNIPROT ID#>>Q8WUM5
  UNIPROT ID#>>I3L2C7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gem nuclear organelle associated protein 4 interacts with:

• B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BRF2 RNA polymerase III transcription initiation factor subunit
  catenin beta like 1
  cell division cycle 20B
  cerebral endothelial cell adhesion molecule
  coiled-coil domain containing 185
  dual specificity phosphatase 26
  egl-9 family hypoxia inducible factor 3
  F-box and leucine rich repeat protein 12
  flavin adenine dinucleotide synthetase 1
  GAR1 ribonucleoprotein
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 6
  gem nuclear organelle associated protein 7
  glyoxylate reductase 1 homolog
  histone deacetylase 11
  HR lysine demethylase and nuclear receptor corepressor
  keratin associated protein 13-2
  keratin associated protein 13-4
  keratin associated protein 15-1
  keratin associated protein 2-3
  keratin associated protein 2-4
  keratin associated protein 9-2
  LEO1 homolog, Paf1/RNA polymerase II complex component
  limb development membrane protein 1 like
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein S16
  MORC family CW-type zinc finger 4
  pleckstrin homology domain containing A4
  protein phosphatase 4 regulatory subunit 2
  purinergic receptor P2Y12
  required for meiotic nuclear division 5 homolog A
  ribosome binding protein 1
  serrate, RNA effector molecule
  SIGLEC family like 1
  sirtuin 7
  SLX1 homolog B, structure-specific endonuclease subunit
  solute carrier family 15 member 3
  SPG21 abhydrolase domain containing, maspardin
  TELO2 interacting protein 2
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  transmembrane protein 41B
  ubiquitin-fold modifier conjugating enzyme 1
  UDP-glucuronate decarboxylase 1
  unc-93 homolog B1, TLR signaling regulator
  WW domain containing oxidoreductase
  zinc finger protein 326

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.