AGO1, argonaute RISC component 1

AGO1, argonaute RISC component 1

• This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

• Gene Synonyms (protein argonaute-1, Golgi Endoplasmic Reticulum protein 95 kDa, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute1, eIF-2C 1, eIF2C 1, eukaryotic translation initiation factor 2C, 1, putative RNA-binding protein Q99, EIF2C, EIF2C1, GERP95, Q99, hAgo1,)
• NCBI Gene ID: 26523
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KME0
  UNIPROT ID#>>B2RAD8
  UNIPROT ID#>>Q9UL18
  UNIPROT ID#>>Q5TA58
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

argonaute RISC component 1 interacts with:

• argonaute RISC catalytic component 2
  argonaute RISC catalytic component 3
  CCR4-NOT transcription complex subunit 7
  coiled-coil domain containing 8
  cullin associated and neddylation dissociated 1
  DDB1 and CUL4 associated factor 10
  decapping mRNA 1A
  decapping mRNA 2
  DnaJ heat shock protein family (Hsp40) member B11
  G protein-coupled receptor associated sorting protein 2
  leucine rich repeat kinase 2
  methylphosphate capping enzyme
  mex-3 RNA binding family member B
  mex-3 RNA binding family member D
  OTU deubiquitinase 7B
  PAT1 homolog 1, processing body mRNA decay factor
  poly(A) binding protein cytoplasmic 1
  trinucleotide repeat containing adaptor 6A
  trinucleotide repeat containing adaptor 6C
  WD repeat and coiled coil containing
  zinc finger CCCH-type containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.