AKAP8, A-kinase anchoring protein 8

AKAP8, A-kinase anchoring protein 8

• This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

• Gene Synonyms (AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchor protein 8, A kinase (PRKA) anchor protein 8, A-kinase anchor protein, 95kDa,)
• NCBI Gene ID: 10270
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43823
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

A-kinase anchoring protein 8 interacts with:

• aurora kinase B
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  cullin associated and neddylation dissociated 1
  developmental pluripotency-associated 3
  EMSY transcriptional repressor, BRCA2 interacting
  F-box and WD repeat domain containing 11
  forkhead box J2
  forkhead box P3
  histone deacetylase 11
  homeodomain interacting protein kinase 4
  integrin alpha FG-GAP repeat containing 1
  L3MBTL histone methyl-lysine binding protein 1
  leucine rich repeat kinase 2
  leucine rich repeats and WD repeat domain containing 1
  limb development membrane protein 1 like
  lysine demethylase 6B
  MIS12 kinetochore complex component
  nuclear RNA export factor 1
  pleckstrin homology domain containing A4
  PR/SET domain 16
  protein tyrosine phosphatase non-receptor type 21
  pyrin and HIN domain family member 1
  ring finger and CCCH-type domains 2
  RuvB like AAA ATPase 2
  testin LIM domain protein
  TNFAIP3 interacting protein 2
  tubulin beta 4B class IVb
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.