LRWD1, leucine rich repeats and WD repeat domain containing 1

LRWD1, leucine rich repeats and WD repeat domain containing 1

• The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

• Gene Synonyms (leucine-rich repeat and WD repeat-containing protein 1, ORC-associated protein, centromere protein 33, origin recognition complex-associated protein, testicular tissue protein Li 4, CENP-33, ORCA,)
• NCBI Gene ID: 222229
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJD0
  UNIPROT ID#>>Q9UFC0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich repeats and WD repeat domain containing 1 interacts with:

• leucine rich repeats and WD repeat domain containing 1
  mitotic spindle organizing protein 2A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.