FAF1, Fas associated factor 1

FAF1, Fas associated factor 1

• Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FAS-associated factor 1, Fas (TNFRSF6) associated factor 1, TNFRSF6-associated factor 1, UBX domain protein 3A, UBX domain-containing protein 12, UBX domain-containing protein 3A, CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1,)
• NCBI Gene ID: 11124
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UNN5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fas associated factor 1 interacts with:

• activating signal cointegrator 1 complex subunit 2
  ASPSCR1 tether for SLC2A4, UBX domain containing
  basic helix-loop-helix family member a15
  BRISC and BRCA1 A complex member 1
  BTB domain containing 9
  calcyclin binding protein
  cell division cycle 73
  chromatin licensing and DNA replication factor 1
  chromobox 3
  coiled-coil-helix-coiled-coil-helix domain containing 10
  CTP synthase 2
  DnaJ heat shock protein family (Hsp40) member B11
  ER lipid raft associated 2
  exportin 7
  family with sequence similarity 114 member A1
  Fas associated factor 1
  Fas associated factor family member 2
  F-box and WD repeat domain containing 11
  F-box protein 45
  glutamate rich WD repeat containing 1
  glutaminyl-peptide cyclotransferase like
  guided entry of tail-anchored proteins factor 4
  heat shock protein family A (Hsp70) member 4 like
  heterogeneous nuclear ribonucleoprotein A3
  hornerin
  kelch like family member 22
  kelch repeat and BTB domain containing 7
  limb development membrane protein 1 like
  MAGI family member, X-linked
  meiosis regulator for oocyte development
  metabolism of cobalamin associated B
  methylphosphate capping enzyme
  MYC binding protein 2
  N-glycanase 1
  NLR family member X1
  NLR family pyrin domain containing 12
  NLR family pyrin domain containing 2
  NLR family pyrin domain containing 3
  NLR family pyrin domain containing 7
  NPL4 homolog, ubiquitin recognition factor
  NSFL1 cofactor
  phosphoglycerate dehydrogenase
  poly(A) binding protein cytoplasmic 1
  poly(U) binding splicing factor 60
  potassium channel tetramerization domain containing 10
  potassium channel tetramerization domain containing 13
  prohibitin 2
  regulator of chromosome condensation 2
  ring finger protein 126
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SEH1 like nucleoporin
  serine/threonine kinase 38
  SERPINE1 mRNA binding protein 1
  sirtuin 6
  Smad nuclear interacting protein 1
  SRP receptor subunit beta
  stomatin like 2
  suprabasin
  switching B cell complex subunit SWAP70
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  tubulin alpha 1c
  tubulin beta 2B class IIb
  tubulin beta class I
  ubiquilin 2
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin protein ligase E3 component n-recognin 4
  UBX domain protein 1
  UBX domain protein 2A
  UBX domain protein 2B
  UBX domain protein 6
  UBX domain protein 7
  valosin containing protein interacting protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 24
  WD repeat domain 26
  WD repeat domain 59
  YTH N6-methyladenosine RNA binding protein 1
  YTH N6-methyladenosine RNA binding protein 2
  YTH N6-methyladenosine RNA binding protein 3
  zinc finger CCCH-type containing 15
  zinc finger CCCH-type containing, antiviral 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.