CTPS2, CTP synthase 2

CTPS2, CTP synthase 2

• The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Gene Synonyms (CTP synthase 2, CTP synthase II, CTP synthetase type 2, UTP-ammonia ligase 2, cytidine 5'-triphosphate synthetase 2,)
• NCBI Gene ID: 56474
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NRF8
  UNIPROT ID#>>A0A024RC00
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CTP synthase 2 interacts with:

• CTP synthase 2
  ectonucleotide pyrophosphatase/phosphodiesterase 6
  leucine rich repeat and sterile alpha motif containing 1
  pleckstrin homology domain containing A4
  SURP and G-patch domain containing 1
  tigger transposable element derived 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.