NLRP2, NLR family pyrin domain containing 2

NLRP2, NLR family pyrin domain containing 2

• This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

• Gene Synonyms (CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NACHT, LRR and PYD domains-containing protein 2, NACHT, leucine rich repeat and PYD containing 2, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2, nucleotide-binding site protein 1,)
• NCBI Gene ID: 55655
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K9G6
  UNIPROT ID#>>Q9NX02
  UNIPROT ID#>>J3KN39
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NLR family pyrin domain containing 2 interacts with:

• NLR family pyrin domain containing 5
  pyrin domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.