- Gene Overview
- Interaction Network
- Sequence Verification
NLRP7, NLR family pyrin domain containing 7
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This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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Gene Synonyms (NACHT, LRR and PYD domains-containing protein 7, NACHT, LRR and PYD containing protein 7, NACHT, leucine rich repeat and PYD containing 7, PYRIN-containing Apaf1-like protein 3, nucleotide-binding oligomerization domain protein 12, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7, CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3,)
- NCBI Gene ID:
199713
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q8WX94
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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NLR family pyrin domain containing 7 interacts with:
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