RNASE1, ribonuclease A family member 1, pancreatic

RNASE1, ribonuclease A family member 1, pancreatic

• This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ribonuclease pancreatic, HP-RNase, RIB-1, RNase 1, RNase A, RNase upI-1, ribonuclease 1, ribonuclease A C1, ribonuclease, RNase A family, 1 (pancreatic), RAC1, RIB1, RNS1,)
• NCBI Gene ID: 6035
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07998
  UNIPROT ID#>>W0UV93
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribonuclease A family member 1, pancreatic interacts with:

• BUD31 homolog
  chromosome 2 open reading frame 49
  nicotinamide nucleotide adenylyltransferase 1
  ribonuclease A family member 1, pancreatic
  ribonuclease/angiogenin inhibitor 1
  tripartite motif containing 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.