NMNAT1, nicotinamide nucleotide adenylyltransferase 1

NMNAT1, nicotinamide nucleotide adenylyltransferase 1

• This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]

• Gene Synonyms (nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, NMN adenylyltransferase 1, NMN/NaMN adenylyltransferase 1, NaMN adenylyltransferase 1, nicotinamide mononucleotide adenylyltransferase 1, nicotinate-nucleotide adenylyltransferase 1, pyridine nucleotide adenylyltransferase 1, LCA9, NMNAT, PNAT1,)
• NCBI Gene ID: 64802
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HAN9
  UNIPROT ID#>>A0A024R4E1
  UNIPROT ID#>>B1AN62
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nicotinamide nucleotide adenylyltransferase 1 interacts with:

• cyclic GMP-AMP synthase
  extra spindle pole bodies 1, separase
  ligand of numb-protein X 1
  lysine rich nucleolar protein 1
  nicotinamide nucleotide adenylyltransferase 1
  nuclear factor of activated T cells 2 interacting protein
  O-sialoglycoprotein endopeptidase
  pyrin and HIN domain family member 1
  RNA binding motif protein 4B
  salt inducible kinase 1
  spire type actin nucleation factor 2
  zinc finger protein 512

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.