UBE2D2, ubiquitin conjugating enzyme E2 D2

UBE2D2, ubiquitin conjugating enzyme E2 D2

• Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 D2, (E3-independent) E2 ubiquitin-conjugating enzyme D2, E2 ubiquitin-conjugating enzyme D2, p53-regulated ubiquitin-conjugating enzyme 1, ubiquitin carrier protein D2, ubiquitin conjugating enzyme E2D 2, ubiquitin-conjugating enzyme E2-17 kDa 2, ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5), ubiquitin-protein ligase D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B,)
• NCBI Gene ID: 7322
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P62837
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 D2 interacts with:

• adenosylhomocysteinase like 1
  ADP ribosylation factor like GTPase 6 interacting protein 6
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  anaphase promoting complex subunit 11
  anaphase promoting complex subunit 2
  AP2 associated kinase 1
  apoptosis resistant E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  arrestin domain containing 3
  baculoviral IAP repeat containing 7
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bifunctional apoptosis regulator
  BRCA1 associated protein
  calcium dependent secretion activator 2
  Cbl proto-oncogene C
  checkpoint with forkhead and ring finger domains
  coiled-coil domain containing 58
  coiled-coil domain containing 88A
  COP1 E3 ubiquitin ligase
  CUE domain containing 1
  cullin 3
  DAZ interacting zinc finger protein 3
  DDB1 and CUL4 associated factor 1
  deltex E3 ubiquitin ligase 2
  deltex E3 ubiquitin ligase 3
  deltex E3 ubiquitin ligase 3L
  DExD/H-box helicase 58
  diphosphoinositol pentakisphosphate kinase 2
  DNA polymerase lambda
  DNA polymerase mu
  F-box and leucine rich repeat protein 3
  F-box and WD repeat domain containing 2
  F-box protein 2
  F-box protein 4
  F-box protein 7
  fibronectin type III and SPRY domain containing 1
  glutamine and serine rich 1
  H3 clustered histone 1
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 4
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  HECT domain E3 ubiquitin protein ligase 1
  HECT domain E3 ubiquitin protein ligase 3
  HECT domain E3 ubiquitin protein ligase 4
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  inhibitor of growth family member 4
  itchy E3 ubiquitin protein ligase
  leucine rich repeat and sterile alpha motif containing 1
  leucine zipper protein 1
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  listerin E3 ubiquitin protein ligase 1
  lysine acetyltransferase 2B
  macrophage erythroblast attacher, E3 ubiquitin ligase
  mahogunin ring finger 1
  makorin ring finger protein 3
  membrane associated ring-CH-type finger 3
  membrane associated ring-CH-type finger 5
  membrane associated ring-CH-type finger 6
  membrane associated ring-CH-type finger 7
  mex-3 RNA binding family member A
  mex-3 RNA binding family member C
  midline 2
  mindbomb E3 ubiquitin protein ligase 1
  mindbomb E3 ubiquitin protein ligase 2
  mitochondrial E3 ubiquitin protein ligase 1
  MYC binding protein 2
  myosin regulatory light chain interacting protein
  N-acetyltransferase 10
  NEDD4 like E3 ubiquitin protein ligase
  neural precursor cell expressed, developmentally down-regulated 4
  neural precursor cell expressed, developmentally down-regulated gene 4-like
  NKD inhibitor of WNT signaling pathway 2
  NSE1 homolog, SMC5-SMC6 complex component
  olfactory receptor family 5 subfamily F member 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PDZ domain containing ring finger 3
  pellino E3 ubiquitin protein ligase 1
  period circadian regulator 2
  PHD and ring finger domains 1
  PHD finger protein 7
  potassium channel modulatory factor 1
  praja ring finger ubiquitin ligase 1
  praja ring finger ubiquitin ligase 2
  RAD18 E3 ubiquitin protein ligase
  RANBP2-type and C3HC4-type zinc finger containing 1
  recombination activating 1
  replication termination factor 2
  required for meiotic nuclear division 5 homolog A
  required for meiotic nuclear division 5 homolog B
  retinol dehydrogenase 12
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger and CHY zinc finger domain containing 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger and SPRY domain containing 1
  ring finger and WD repeat domain 3
  ring finger protein 10
  ring finger protein 103
  ring finger protein 11
  ring finger protein 111
  ring finger protein 112
  ring finger protein 114
  ring finger protein 115
  ring finger protein 115
  ring finger protein 122
  ring finger protein 123
  ring finger protein 125
  ring finger protein 126
  ring finger protein 13
  ring finger protein 130
  ring finger protein 135
  ring finger protein 138
  ring finger protein 14
  ring finger protein 146
  ring finger protein 150
  ring finger protein 151
  ring finger protein 165
  ring finger protein 166
  ring finger protein 167
  ring finger protein 168
  ring finger protein 170
  ring finger protein 181
  ring finger protein 185
  ring finger protein 186
  ring finger protein 19A, RBR E3 ubiquitin protein ligase
  ring finger protein 19B
  ring finger protein 20
  ring finger protein 213
  ring finger protein 216
  ring finger protein 220
  ring finger protein 224
  ring finger protein 25
  ring finger protein 26
  ring finger protein 31
  ring finger protein 34
  ring finger protein 38
  ring finger protein 40
  ring finger protein 43
  ring finger protein 7
  ring finger protein 8
  ring finger protein, LIM domain interacting
  ring-box 1
  SEC24 homolog B, COPII coat complex component
  sequestosome 1
  signal transducing adaptor molecule 2
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  speckle type BTB/POZ protein
  sprouty RTK signaling antagonist 2
  STIP1 homology and U-box containing protein 1
  suppressor of cytokine signaling 6
  synoviolin 1
  Tax1 binding protein 3
  THAP domain containing 8
  thyroid hormone receptor interactor 12
  TNF receptor associated factor 7
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF interacting protein
  tripartite motif containing 10
  tripartite motif containing 11
  tripartite motif containing 13
  tripartite motif containing 17
  tripartite motif containing 2
  tripartite motif containing 25
  tripartite motif containing 26
  tripartite motif containing 28
  tripartite motif containing 3
  tripartite motif containing 31
  tripartite motif containing 32
  tripartite motif containing 33
  tripartite motif containing 35
  tripartite motif containing 36
  tripartite motif containing 38
  tripartite motif containing 39
  tripartite motif containing 41
  tripartite motif containing 43
  tripartite motif containing 45
  tripartite motif containing 46
  tripartite motif containing 47
  tripartite motif containing 5
  tripartite motif containing 50
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 62
  tripartite motif containing 63
  tripartite motif containing 65
  tripartite motif containing 7
  tripartite motif containing 8
  ubiquilin 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 F (putative)
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 R2
  ubiquitin conjugating enzyme E2 V1
  ubiquitin D
  ubiquitin domain containing 1
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 3
  ubiquitin like modifier activating enzyme 5
  ubiquitin like modifier activating enzyme 6
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 2
  ubiquitin protein ligase E3 component n-recognin 3
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 9 X-linked
  ubiquitination factor E4A
  ubiquitination factor E4B
  U-box domain containing 5
  UBX domain protein 7
  UV stimulated scaffold protein A
  von Hippel-Lindau tumor suppressor
  VPS11 core subunit of CORVET and HOPS complexes
  VPS18 core subunit of CORVET and HOPS complexes
  WD repeat and SOCS box containing 1
  WRN RecQ like helicase
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  zinc and ring finger 1
  zinc and ring finger 2
  zinc and ring finger 4
  zinc finger protein 598, E3 ubiquitin ligase
  zinc ribbon domain containing 2
  ZPR1 zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.