TRIM5, tripartite motif containing 5

TRIM5, tripartite motif containing 5

• The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

• Gene Synonyms (tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, ring finger protein 88, tripartite motif containing 5 transcript variant iota, tripartite motif containing 5 transcript variant kappa, tripartite motif protein TRIM5, RNF88, TRIM5alpha,)
• NCBI Gene ID: 85363
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9C035
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tripartite motif containing 5 interacts with:

• CUE domain containing 1
  maturin, neural progenitor differentiation regulator homolog
  membrane palmitoylated protein 7
  OTU deubiquitinase 6A
  testis specific 10 interacting protein
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  tripartite motif containing 5
  tripartite motif containing 6
  ubiquitin conjugating enzyme E2 U

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.