TRIP12, thyroid hormone receptor interactor 12

TRIP12, thyroid hormone receptor interactor 12

• The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

• Gene Synonyms (E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf, HECT-type E3 ubiquitin transferase TRIP12, TR-interacting protein 12, probable E3 ubiquitin-protein ligase TRIP12, thyroid receptor interacting protein 12, MRD49, TRIP-12, TRIPC, ULF,)
• NCBI Gene ID: 9320
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14669
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thyroid hormone receptor interactor 12 interacts with:

• activating transcription factor 7 interacting protein
  Aly/REF export factor
  autophagy related 16 like 1
  calsyntenin 1
  carnosine synthase 1
  centrosomal protein 19
  coiled-coil domain containing 8
  decapping enzyme, scavenger
  G protein nucleolar 3
  heterogeneous nuclear ribonucleoprotein F
  karyopherin subunit alpha 6
  kelch repeat and BTB domain containing 7
  kinectin 1
  kinesin family member 20A
  limb development membrane protein 1 like
  mediator of DNA damage checkpoint 1
  methylphosphate capping enzyme
  obscurin like cytoskeletal adaptor 1
  pancreas associated transcription factor 1a
  PHD finger protein 8
  pleckstrin homology domain containing A4
  ring finger protein 123
  ring finger protein 168
  sirtuin 7
  SNW domain containing 1
  SRY-box transcription factor 6
  SUZ12 polycomb repressive complex 2 subunit
  terminal nucleotidyltransferase 5A
  tripartite motif containing 28
  tubulin, gamma complex associated protein 5
  ubiquitination factor E4B
  vir like m6A methyltransferase associated
  WD repeat domain 76

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.