RNF19A, ring finger protein 19A, RBR E3 ubiquitin protein ligase

RNF19A, ring finger protein 19A, RBR E3 ubiquitin protein ligase

• This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF19A, double ring-finger protein, protein p38 interacting with transcription factor Sp1, ring finger protein 19, ring finger protein 19A, E3 ubiquitin protein ligase, ring-IBR-ring domain containing protein Dorfin, RNF19,)
• NCBI Gene ID: 25897
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NV58
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 19A, RBR E3 ubiquitin protein ligase interacts with:

• mitogen-activated protein kinase kinase kinase 20
  SUFU negative regulator of hedgehog signaling
  tubulin gamma 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.