RBX1, ring-box 1

RBX1, ring-box 1

• This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

• Gene Synonyms (E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein transferase RBX1, RING finger protein 75, RING-box protein 1, ZYP protein, regulator of cullins 1, ring-box 1, E3 ubiquitin protein ligase, BA554C12.1, RNF75, ROC1,)
• NCBI Gene ID: 9978
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P62877
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring-box 1 interacts with:

• actin beta like 2
  Aly/REF export factor
  ankyrin repeat and BTB domain containing 2
  anoctamin 7
  ariadne RBR E3 ubiquitin protein ligase 1
  armadillo repeat containing 6
  AT-rich interaction domain 1B
  ATRX, chromatin remodeler
  autophagy and beclin 1 regulator 1
  bromodomain and WD repeat domain containing 3
  cAMP responsive element binding protein 3 like 3
  centromere protein W
  cereblon
  chaperonin containing TCP1 subunit 2
  chromatin target of PRMT1
  chromobox 1
  chromobox 3
  chromobox 5
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  COP9 signalosome subunit 9
  coronin 7
  cullin 1
  cullin 3
  cullin 4A
  cullin 9
  cullin associated and neddylation dissociated 1
  cullin associated and neddylation dissociated 2 (putative)
  C-X9-C motif containing 2
  cyclic GMP-AMP synthase
  cysteine and serine rich nuclear protein 3
  cysteine rich with EGF like domains 1
  DAB2 interacting protein
  damage specific DNA binding protein 1
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 13
  defective in cullin neddylation 1 domain containing 1
  defective in cullin neddylation 1 domain containing 2
  defective in cullin neddylation 1 domain containing 3
  defective in cullin neddylation 1 domain containing 4
  defective in cullin neddylation 1 domain containing 5
  denticleless E3 ubiquitin protein ligase
  denticleless E3 ubiquitin protein ligase homolog
  DET1 and DDB1 associated 1
  DET1 partner of COP1 E3 ubiquitin ligase
  DExD-box helicase 39A
  DnaJ heat shock protein family (Hsp40) member A2
  erbb2 interacting protein
  F-box and leucine rich repeat protein 12
  F-box and leucine rich repeat protein 15
  F-box and leucine rich repeat protein 5
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 2
  F-box and WD repeat domain containing 7
  F-box and WD repeat domain containing 8
  F-box DNA helicase 1
  F-box protein 11
  F-box protein 17
  F-box protein 2
  F-box protein 21
  F-box protein 22
  F-box protein 25
  F-box protein 27
  F-box protein 3
  F-box protein 31
  F-box protein 32
  F-box protein 42
  F-box protein 44
  F-box protein 6
  F-box protein 7
  fem-1 homolog B
  FtsJ RNA 2'-O-methyltransferase 3
  glomulin, FKBP associated protein
  glucosidase II alpha subunit
  glycosyltransferase 8 domain containing 2
  H2A clustered histone 19
  H2A clustered histone 21
  H2A.Z variant histone 2
  H2B.U histone 1
  H4 histone 16
  HCLS1 associated protein X-1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family H (Hsp110) member 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  importin 4
  inhibitor of Bruton tyrosine kinase
  inhibitor of growth family member 3
  innate immunity activator
  kelch like family member 18
  kelch like family member 3
  kelch like family member 41
  kelch like family member 7
  kelch repeat and BTB domain containing 6
  kelch repeat and BTB domain containing 7
  keratin associated protein 12-2
  KH RNA binding domain containing, signal transduction associated 1
  LDL receptor related protein 1B
  leucine rich repeat protein 1
  leucine rich repeat protein 1
  limb development membrane protein 1 like
  lysine demethylase 2B
  lysine methyltransferase 5A
  MAGE family member C2
  mediator complex subunit 8
  methylcrotonoyl-CoA carboxylase 1
  methylcrotonoyl-CoA carboxylase 2
  mindbomb E3 ubiquitin protein ligase 1
  minichromosome maintenance 10 replication initiation factor
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase kinase kinase 20
  mitogen-activated protein kinase kinase kinase kinase 1
  NEDD8-MDP1 readthrough
  nicotinamide phosphoribosyltransferase
  NLR family pyrin domain containing 3
  obscurin like cytoskeletal adaptor 1
  OS9 endoplasmic reticulum lectin
  PBX homeobox 4
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphoglycerate dehydrogenase
  poly(A) binding protein cytoplasmic 1
  potassium channel tetramerization domain containing 17
  PRAME nuclear receptor transcriptional regulator
  pyrin and HIN domain family member 1
  RALY heterogeneous nuclear ribonucleoprotein
  Rap guanine nucleotide exchange factor 6
  receptor interacting serine/threonine kinase 4
  Rho related BTB domain containing 3
  ribosomal protein L13a
  ribosomal protein L36
  ring finger protein 126
  ring-box 1
  RNA binding motif protein X-linked
  RNA binding protein with serine rich domain 1
  RPTOR independent companion of MTOR complex 2
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  serine and arginine rich splicing factor 10
  SERTA domain containing 1
  sestrin 1
  sestrin 2
  shroom family member 4
  sidekick cell adhesion molecule 2
  signal recognition particle 72
  SNF2 histone linker PHD RING helicase
  spindle apparatus coiled-coil protein 1
  stromal cell derived factor 4
  syntaxin 6
  TAR DNA binding protein
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  transient receptor potential cation channel subfamily C member 4 associated protein
  tripartite motif containing 28
  tripartite motif containing 74
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha like 3
  tubulin beta 2B class IIb
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 R2
  UBX domain protein 1
  UBX domain protein 7
  WD and tetratricopeptide repeats 1
  WD repeat domain 82
  YTH N6-methyladenosine RNA binding protein 1
  zinc finger C3HC-type containing 1
  zinc finger protein 835

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.