FBXO32, F-box protein 32

FBXO32, F-box protein 32

• This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

• Gene Synonyms (Fbx32, MAFbx, F-box only protein 32, atrogin 1, muscle atrophy F-box protein,)
• NCBI Gene ID: 114907
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q498Y9
  UNIPROT ID#>>Q0VAQ6
  UNIPROT ID#>>A0A024R9F3
  UNIPROT ID#>>I6L984
  UNIPROT ID#>>Q969P5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box protein 32 interacts with:

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