SRSF10, serine and arginine rich splicing factor 10

SRSF10, serine and arginine rich splicing factor 10

• This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2, serine/arginine-rich splicing factor 10, 40 kDa SR-repressor protein, FUS interacting protein (serine-arginine rich) 1, FUS-interacting protein (serine-arginine rich) 2, SR splicing factor 10, TLS-associated SR protein, TLS-associated protein TASR, TLS-associated protein with SR repeats, TLS-associated protein with Ser-Arg repeats, TLS-associated serine-arginine protein 1, TLS-associated serine-arginine protein 2, neural-salient SR protein, protein phosphatase 1, regulatory subunit 149, serine-arginine repressor protein (40 kDa), splicing factor SRp38, splicing factor, arginine/serine-rich 13, splicing factor, arginine/serine-rich 13A,)
• NCBI Gene ID: 10772
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5JRI1
  UNIPROT ID#>>A0A0S2Z504
  UNIPROT ID#>>O75494
  UNIPROT ID#>>B3KNY6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine and arginine rich splicing factor 10 interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  B9 domain containing 2
  Cbl proto-oncogene like 2
  centrosomal protein 164
  cullin associated and neddylation dissociated 1
  ER membrane protein complex subunit 1
  F-box protein 7
  G-protein signalling modulator 1 (AGS3-like, C. elegans)
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  leucine zipper protein 4
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  methyltransferase like 14
  mitotic spindle organizing protein 1
  nicastrin
  NKAP domain containing 1
  obscurin like cytoskeletal adaptor 1
  PAX interacting protein 1
  phosphoglycerate dehydrogenase
  pyrin and HIN domain family member 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 31
  RNA binding protein with serine rich domain 1
  SLAIN motif family member 2
  Smad nuclear interacting protein 1
  small glutamine rich tetratricopeptide repeat containing beta
  SMU1 DNA replication regulator and spliceosomal factor
  splicing regulatory glutamic acid and lysine rich protein 1
  SUZ12 polycomb repressive complex 2 subunit
  synaptonemal complex central element protein 1 like
  THO complex 6
  transcription elongation regulator 1
  transformer 2 alpha homolog
  tripartite motif containing 55
  tRNA methyltransferase subunit 11-2
  tubulin gamma complex associated protein 2
  tubulin, gamma 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  UTP14A small subunit processome component
  vasorin
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger CCCH-type containing 18
  zinc finger protein 687

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.