ING3, inhibitor of growth family member 3

ING3, inhibitor of growth family member 3

• The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (inhibitor of growth protein 3, Eaf4, ING2, MEAF4, p47ING3,)
• NCBI Gene ID: 54556
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NXR8
  UNIPROT ID#>>B7ZKQ7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inhibitor of growth family member 3 interacts with:

• brain expressed X-linked 5
  DNA methyltransferase 1 associated protein 1
  E1A binding protein p400
  enhancer of polycomb homolog 1
  forkhead box R1
  forkhead box R2
  H2B clustered histone 1
  mbt domain containing 1
  MRG domain binding protein
  MYST/Esa1 associated factor 6
  NFKB activating protein
  RuvB-like protein 1
  testis expressed 11
  tripartite motif containing 54
  USH1 protein network component harmonin binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.