IBTK, inhibitor of Bruton tyrosine kinase

IBTK, inhibitor of Bruton tyrosine kinase

• Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

• Gene Synonyms (inhibitor of Bruton tyrosine kinase, BTK-binding protein, Bruton agammaglobulinemia tyrosine kinase inhibitor, inhibitor of Bruton's tyrosine kinase-alpha, inhibitor of Bruton's tyrosine kinase-beta, inhibitor of Bruton's tyrosine kinase-gamma, BTBD26, BTKI,)
• NCBI Gene ID: 25998
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P2D0
  UNIPROT ID#>>E7EPI0
  UNIPROT ID#>>B7ZLE0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inhibitor of Bruton tyrosine kinase interacts with:

• B9 domain containing 2
  BCL6 corepressor
  centromere protein J
  centrosomal protein 120
  centrosomal protein 128
  centrosomal protein 44
  CLIP associating protein 2
  COP9 signalosome subunit 4
  cullin associated and neddylation dissociated 1
  developmental pluripotency associated 4
  DOT1 like histone lysine methyltransferase
  egl-9 family hypoxia inducible factor 3
  hypoxia inducible factor 1 subunit alpha inhibitor
  immunoglobulin superfamily member 8
  inhibitor of Bruton tyrosine kinase
  lactamase beta
  mindbomb E3 ubiquitin protein ligase 1
  MSL complex subunit 1
  N-acetyltransferase 10
  Nanog homeobox
  polycomb group ring finger 1
  programmed cell death 4
  ribonuclease P/MRP subunit p25 like
  ribosome binding protein 1
  RPGR interacting protein 1
  RuvB-like protein 1
  TSR1 ribosome maturation factor
  WD repeat domain 74
  zinc finger CCCH-type containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.