FBH1, F-box DNA helicase 1

FBH1, F-box DNA helicase 1

• This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (F-box DNA helicase 1, F-box only protein, helicase, 18, F-box protein, helicase, 18, FBXO18, Fbx18, hFBH1,)
• NCBI Gene ID: 84893
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KV95
  UNIPROT ID#>>Q2TAK1
  UNIPROT ID#>>Q8NFZ0
  UNIPROT ID#>>F6UZG9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box DNA helicase 1 interacts with:

• mitochondrial ribosome recycling factor

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