RNF216, ring finger protein 216

RNF216, ring finger protein 216

• This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF216, RING-type E3 ubiquitin transferase RNF216, triad domain-containing protein 3, ubiquitin-conjugating enzyme 7-interacting protein 1, zinc finger protein inhibiting NF-kappa-B, CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN,)
• NCBI Gene ID: 54476
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K8N1
  UNIPROT ID#>>Q9NWF9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 216 interacts with:

• ring finger protein 216
  TIR domain containing adaptor protein
  toll like receptor adaptor molecule 1
  ubiquitin associated and SH3 domain containing B
  YOD1 deubiquitinase
  zinc finger AN1-type containing 2A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.