ARIH2, ariadne RBR E3 ubiquitin protein ligase 2

ARIH2, ariadne RBR E3 ubiquitin protein ligase 2

• The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

• Gene Synonyms (ARI2, TRIAD1, E3 ubiquitin-protein ligase ARIH2, RING-type E3 ubiquitin transferase ARIH2, all-trans retinoic acid inducible RING finger, ariadne homolog 2, protein ariadne-2 homolog,)
• NCBI Gene ID: 10425
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IBL8
  UNIPROT ID#>>Q53ET9
  UNIPROT ID#>>O95376
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ariadne RBR E3 ubiquitin protein ligase 2 interacts with:

• 5'-3' exoribonuclease 2
  ADP ribosylation factor like GTPase 6 interacting protein 4
  ankyrin repeat and SOCS box containing 3
  ankyrin repeat and SOCS box containing 6
  ankyrin repeat and SOCS box containing 9
  apolipoprotein B mRNA editing enzyme catalytic subunit 3F
  apolipoprotein B mRNA editing enzyme catalytic subunit 3G
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  ariadne RBR E3 ubiquitin protein ligase 2
  biogenesis of ribosomes BRX1
  bromodomain adjacent to zinc finger domain 1A
  centrosomal protein 126
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 33
  cullin associated and neddylation dissociated 1
  DAZ associated protein 1
  DEAD-box helicase 17
  defective in cullin neddylation 1 domain containing 1
  dermcidin
  DISC1 scaffold protein
  DnaJ heat shock protein family (Hsp40) member C10
  EH domain containing 1
  EMAP like 4
  exosome component 6
  exosome component 7
  glutamate rich WD repeat containing 1
  glutaminyl-peptide cyclotransferase
  H2B clustered histone 12
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein U like 1
  histone deacetylase 8
  insulin like growth factor 2 mRNA binding protein 1
  keratin 72
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  lysine acetyltransferase 5
  NFKB repressing factor
  NLR family pyrin domain containing 3
  NOP2/Sun RNA methyltransferase 2
  NPR2 like, GATOR1 complex subunit
  opioid growth factor receptor
  Parkinsonism associated deglycase
  peroxiredoxin 3
  PHD finger protein 7
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(ADP-ribose) polymerase family member 6
  protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
  PWP1 homolog, endonuclein
  PYD and CARD domain containing
  RAB1B, member RAS oncogene family
  RAB40A, member RAS oncogene family
  RBMX like 2
  ribosomal protein L13a
  ribosomal protein L36
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA transcription, translation and transport factor
  SEC23 interacting protein
  SERPINE1 mRNA binding protein 1
  solute carrier family 39 member 9
  splicing factor 3b subunit 3
  synaptotagmin binding cytoplasmic RNA interacting protein
  trinucleotide repeat containing adaptor 6A
  trinucleotide repeat containing adaptor 6B
  trinucleotide repeat containing adaptor 6C
  tubulin beta class I
  twinfilin actin binding protein 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 R2
  ubiquitin conjugating enzyme E2 T
  UTP14A small subunit processome component
  vacuolar protein sorting 45 homolog
  WD repeat and SOCS box containing 1
  WD repeat and SOCS box containing 2
  WD repeat domain 91
  WW domain containing oxidoreductase
  ZFP41 zinc finger protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.