VPS45, vacuolar protein sorting 45 homolog

VPS45, vacuolar protein sorting 45 homolog

• Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

• Gene Synonyms (vacuolar protein sorting-associated protein 45, leucocyte vacuolar protein sorting 45, vacuolar protein sorting 45A, H1, H1VPS45, SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A,)
• NCBI Gene ID: 11311
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z360
  UNIPROT ID#>>B7Z5D4
  UNIPROT ID#>>Q9NRW7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

vacuolar protein sorting 45 homolog interacts with:

• ADP ribosylation factor GTPase activating protein 2
  ADP ribosylation factor like GTPase 5B
  centrosomal protein 128
  centrosomal protein 152
  cullin associated and neddylation dissociated 1
  egl-9 family hypoxia inducible factor 3
  EH domain containing 4
  G protein-coupled receptor class C group 5 member D
  histone deacetylase 8
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  lipolysis stimulated lipoprotein receptor
  ninein like
  NIPA like domain containing 3
  RAB guanine nucleotide exchange factor 1
  RAB1B, member RAS oncogene family
  rabenosyn, RAB effector
  sec1 family domain containing 1
  SEC31 homolog A, COPII coat complex component
  secretion associated Ras related GTPase 1A
  solute carrier family 39 member 4
  solute carrier family 39 member 9
  syntaxin 12
  syntrophin gamma 1
  TBL1X receptor 1
  trafficking protein particle complex 11
  trafficking protein particle complex 2 like
  trafficking protein particle complex 5
  transmembrane protein 17
  transmembrane protein 171
  VPS11 core subunit of CORVET and HOPS complexes
  VPS18 core subunit of CORVET and HOPS complexes
  VPS33A core subunit of CORVET and HOPS complexes
  VPS53 subunit of GARP complex
  zinc finger protein 827

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.